Publications | The Fenton Lab

Recent Publications from the Fenton Lab

For most recent publications from the lab, please click below:

50. A Chemoinformatic-Guided Synthesis of a Spleen-Expressing mRNA Lipid Nanoparticle Platform

Eshan A Narasipura, Yutian Ma, Palas Balakdas Tiwade, Rachel VanKeulen-Miller, Vincent Fung, Owen S Fenton*

Bioconjugate Chemistry

2025

49. Polymeric cGAMP Microparticles Affect the Immunogenicity of a Broadly Active Influenza mRNA Lipid Nanoparticle Vaccine

Dylan A Hendy, Yutian Ma, Timothy A Dixon, Connor T Murphy, Erik S Pena, Michael A Carlock, Ted M Ross, Eric M Bachelder, Kristy M Ainslie, Owen S Fenton*

Journal of Controlled Release

2024

48. A Lung-Expressing mRNA Delivery Platform with Tunable Activity in Hypoxic Environments

Palas Balakdas Tiwade, Yutian Ma, Rachel VanKeulen-Miller, and Owen S. Fenton*

Journal of the American Chemical Society

2024

47. Regioselective Palladium-Catalyzed Chain-Growth Allylic Amination Polymerization of Vinyl Aziridines

Jake R Jagannathan, Yutian Ma, Brennen J Curole, Scott M Grayson, Owen S Fenton, Frank A Leibfarth*

Journal of the American Chemical Society

2024

46. Polyphenolic Nanoparticle Platforms (PARCELs) for In Vitro and In Vivo mRNA Delivery

Yutian Ma, Palas B Tiwade, Rachel VanKeulen-Miller, Eshan A Narasipura, Owen S Fenton*

Nano Letters

2024

45. Voices in Molecular Pharmaceutics: Meet Professor Owen S. Fenton, Designer of Lipid Nanoparticles for Messenger RNA Delivery

Owen S Fenton*

Molecular Pharmaceutics

2024

44. Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays

Cassandra L. Clift, Mark C. Blaser, Willem Gerrits, Mandy E. Turner, Abhijeet R. Sonawane, Tan Pham, Jason L. Andresen, Owen S. Fenton, Joshua M. Grolman, Fabrizio Buffolo, Frederick J. Schoen, Jesper Hjortnaes, Jochen D. Muehlschlegel, David J. Mooney, Masanori Aikawa, Sasha A. Singh, Robert Langer, Elena Aikawa*

Science Advances

2024

43. Nanoparticle‐mediated Delivery of Anti‐PU. 1 Sirna via Localized Intracisternal Administration Reduces Neuroinflammation

William T Ralvenius, Jason L Andresen, Margaret M Huston, Jay Penney, Julia Maeve Bonner, Owen S Fenton*, Robert Langer*, Li‐Huei Tsai*.

Advanced Materials, 2309225

2024

42. Enhancing the Functionality of Immunoisolated Human SC‐βeta Cell Clusters through Prior Resizing

Matthew A Bochenek, Ben Walters, Jingping Zhang, Owen S Fenton, Amanda Facklam, Zuzana Kroneková, Michal Pelach, Elise N Engquist, Nayara C Leite, Alex Morgart, Igor Lacík, Robert Langer, Daniel G Anderson*

Small, 2307464

2024

41. Messenger RNA Therapy for Female Reproductive Health

Rachel Vankeulen-Miller, Owen S Fenton*

Molecular Pharmaceutics

2024

40. Advances in non-viral mRNA delivery to the spleen

Eshan A Narasipura, Owen S Fenton*

Biomaterials Science

2024

39. Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy

Bevin Neill, Adriana R Romero, Owen S Fenton*

ACS Applied Bio Materials

2023

38. A Unified Strategy to Improve Lipid Nanoparticle Mediated mRNA Delivery Using Adenosine Triphosphate

Yutian Ma, Owen S Fenton*

Journal of the American Chemical Society 145 (36), 19800-19811

2023

37. Engineering nanoparticle toolkits for mRNA delivery

Bing Sun, Weixi Wu, Eshan A Narasipura, Yutian Ma, Chengzhong Yu, Owen S Fenton*, Hao Song*

Advanced Drug Delivery Reviews, 115042

2023

36. Ongoing clinical trials of nonviral siRNA therapeutics

Eshan A Narasipura, Rachel VanKeulen-Miller, Yutian Ma, Owen S Fenton*

Bioconjugate Chemistry 34 (7), 1177-1197

2023

35. An Efficacy and Mechanism Driven Study on the Impact of Hypoxia on Lipid Nanoparticle Mediated mRNA Delivery

Yutian Ma, Owen S Fenton*

Journal of the American Chemical Society

2023

34. Tannic Acid Lipid Nanoparticles Can Deliver Messenger RNA Payloads and Improve Their Endosomal Escape

Yutian Ma, Owen S Fenton*

Advanced Therapeutics, 2200305

2023

33. Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays

Cassandra L Clift, Mark C Blaser, Willem Gerrits, Mandy E Turner, Abhijeet C Sonawane, Tan Pham, Jason L Andresen, Owen S Fenton, Joshua M Grolman, Fabrizio Buffolo, Frederick J Schoen, Jesper Hjortnaes, Jochen Daniel Muehlschlegel, David Daniel Mooney, Masanori Aikawa, Sasha A Singh, Robert Langer, Elena Aikawa.*

Science Advances

2023

32. Single-tailed heterocyclic carboxamide lipids for macrophage immune-modulation

Kuo-Ching Mei, Rebeca T Stiepel, Emily Bonacquisti, Natalie E Jasiewicz, Ameya Pravin Chaudhari, Palas B Tiwade, Eric M Bachelder, Kristy M Ainslie, Owen S Fenton, Juliane Nguyen*

Biomaterials Science 11 (8), 2693-2698

2023

31. Multi-Omics Driven Assessment of Pathobiology in a 3D-Bioprinted Aortic Valve Disease Model Compared to Native Valves and 2D Culture

Cassandra L Clift, Mark C Blaser, Willem Gerrits, Tan Pham, Mandy E Turner, Jason L Andresen, Owen S Fenton, Joshua M Grolman, Gabrizio Buffolo, David J Mooney, Jesper Hjortnaes, Jochen D Muehlschlegel, Masanori Aikawa, Robert Langer, Elena Aikawa*

MOLECULAR & CELLULAR PROTEOMICS 21 (8), S38-S38

2022

30. Additive Manufacturing Approaches toward the Fabrication of Biomaterials

Florence J Müller, Owen S Fenton*

Advanced Materials Interfaces 9 (7), 2100670

2022

29. Nucleic acid delivery and nanoparticle design for COVID vaccines

Jason L Andresen, Owen S Fenton*

Mrs Bulletin, 1-8

2021

GRADUATE AND POST-DOCTORAL TRAINING

28. A nanoprimer to improve the systemic delivery of siRNA and mRNA

Nell RM Saunders, Marion S Paolini, Owen S Fenton, Laurence Poul, Julie Devalliere, Francis Mpambani, Audrey Darmon, Maxime Bergère, Océane Jibault, Matthieu Germain, Robert Langer

Nano Letters 20 (6), 4264-4269

2020

27. Outlooks on three-dimensional printing for ocular biomaterials research

OS Fenton, M Paolini, JL Andresen, FJ Müller, R Langer

Journal of ocular pharmacology and therapeutics 36 (1), 7-17

2020

26. Injectable polymer–nanoparticle hydrogels for local immune cell recruitment

OS Fenton, MW Tibbitt, EA Appel, S Jhunjhunwala, MJ Webber, R Langer

Biomacromolecules 20 (12), 4430-4436

2019

25. Polymers for extended-release administration

MS Paolini, OS Fenton, C Bhattacharya, JL Andresen, R Langer

Biomedical Microdevices 21, 1-24

2019

24. β‐Aminoacrylate Synthetic Hydrogels: Easily Accessible and Operationally Simple Biomaterials Networks

OS Fenton, JL Andresen, M Paolini, R Langer

Angewandte Chemie 130 (49), 16258-16261

2018

23. Customizable lipid nanoparticle materials for the delivery of siRNAs and mRNAs

Owen S Fenton, Kevin J Kauffman, Rebecca L McClellan, James C Kaczmarek, Manhao D Zeng, Jason L Andresen, Luke H Rhym, Michael W Heartlein, Frank DeRosa, Daniel G Anderson

Angewandte Chemie International Edition 57 (41), 13582-13586

2018

22. Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells

James C Kaczmarek, Kevin J Kauffman, Owen S Fenton, Kaitlyn Sadtler, Asha K Patel, Michael W Heartlein, Frank DeRosa, Daniel G Anderson

Nano letters 18 (10), 6449-6454

2018

21. Poly(β‐amino ester)‐co‐poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo

U Capasso Palmiero, JC Kaczmarek, OS Fenton, DG Anderson

Advanced Healthcare Materials 7 (14), 1800249

2018

20. Advances in biomaterials for drug delivery

OS Fenton, KN Olafson, PS Pillai, MJ Mitchell, R Langer

Advanced Materials 30 (29), 1705328

2018

19. Biomanufacturing for clinically advanced cell therapies

Ayesha Aijaz, Matthew Li, David Smith, Danika Khong, Courtney LeBlon, Owen S Fenton, Ronke M Olabisi, Steven Libutti, Jay Tischfield, Marcela V Maus, Robert Deans, Rita N Barcia, Daniel G Anderson, Jerome Ritz, Robert Preti, Biju Parekkadan

Nature biomedical engineering 2 (6), 362-376

2018

18. Engineering a 3D-bioprinted model of human heart valve disease using nanoindentation-based biomechanics

Dewy C Van der Valk, Casper FT Van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain Van Mil, Carlijn VC Bouten, Simon C Body, David J Mooney, Joost PG Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa

Nanomaterials 8 (5), 296

2018

17. Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes

Owen S. Fenton, Kevin J. Kauffman, James C. Kaczmarek, Rebecca L. McClellan, Siddharth Jhunjhunwala, Mark W. Tibbitt, Manhao D. Zeng, Eric A. Appel, Joseph R. Dorkin, Faryal F. Mir, Jung H. Yang, Matthias A. Oberli, Michael W. Heartlein, Frank DeRosa, Robert Langer, Daniel G. Anderson

Advanced Materials 29 (33), 1606944

2017

16. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy

Matthias A Oberli, Andreas M Reichmuth, J Robert Dorkin, Michael J Mitchell, Owen S Fenton, Ana Jaklenec, Daniel G Anderson, Robert Langer, Daniel Blankschtein

Nano letters 17 (3), 1326-1335

2017

15. Polymer–lipid nanoparticles for systemic delivery of mRNA to the lungs

James C Kaczmarek, Asha K Patel, Kevin J Kauffman, Owen S Fenton, Matthew J Webber, Michael W Heartlein, Frank DeRosa, Daniel G Anderson

Angewandte Chemie 128 (44), 14012-14016

2016

14. Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery

Owen S Fenton, Kevin J Kauffman, Rebecca L McClellan, Eric A Appel, J Robert Dorkin, Mark W Tibbitt, Michael W Heartlein, Frank DeRosa, Robert Langer, Daniel G Anderson

Advanced materials 28 (15), 2939-2943

2016

13. Poly (limonene thioether) scaffold for tissue engineering

KM Fischer, KY Morgan, K Hearon, D Sklaviadis, ZL Tochka, OS Fenton, ...

Advanced healthcare materials 5 (7), 813-821

2016

12. Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A

RP Loach, OS Fenton, M Movassaghi

Journal of the American Chemical Society 138 (3), 1057-1064

2016

11. Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs

Kristin M Fischer, Kathy Ye Morgan, Keith Hearon, Demetra Sklaviadis, Zachary L Tochka, Owen S Fenton, Daniel G Anderson, Robert Langer, Lisa E Freed

Nano letters 15 (11), 7300-7306

2015

10. Exploiting electrostatic interactions in polymer–nanoparticle hydrogels

Eric A Appel, Mark W Tibbitt, Jessica M Greer, Owen S Fenton, Klaus Kreuels, Daniel G Anderson, Robert Langer

ACS Macro Letters 4 (8), 848-852

2015

9. C7-derivatization of C3-alkylindoles including tryptophans and tryptamines

RP Loach, OS Fenton, K Amaike, DS Siegel, E Ozkal, M Movassaghi

The Journal of organic chemistry 79 (22), 11254-11263

2014

8. Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Kathryn A Whitehead, J Robert Dorkin, Arturo J Vegas, Philip H Chang, Omid Veiseh, Jonathan Matthews, Owen S Fenton, Yunlong Zhang, Karsten T Olejnik, Volkan Yesilyurt, Delai Chen, Scott Barros, Boris Klebanov, Tatiana Novobrantseva, Robert Langer, Daniel G Anderson

Nature communications 5 (1), 4277

2014

7. Catalytic Lewis acid phosphorylation with pyrophosphates

OS Fenton, EE Allen, KP Pedretty, SD Till, JE Todaro, BR Sculimbrene

Tetrahedron 68 (44), 9023-9028

2012

6. A general entry to C7-borono indole derivatives

OS Fenton

Massachusetts Institute of Technology

2012

5. A Wet-Lab Approach to Stereochemistry Using 31P NMR Spectroscopy

OS Fenton, BR Sculimbrene